by Alpesh Patel (Author), Girish Patel (Author), Alpesh D. Patel (Author)
The present invention is aimed to formulate the "non-enteric" formulation of immediate release rabeprazole sodium tablet using acid-buffer technology. The formulation comprising the core tablet containing rabeprazole sodium compression coated with buffer containing super disintegrant. The coat formulation disintegrates fast which provide the higher pH environment then the core formulation gives drug release so degradation of rabeprazole sodium can prevent. From the above perception, the invention is aimed: 1.To study the pH stability of rabeprazole sodium in at different pH medium. 2.To select the proper buffer combination for better basic environment. 3.To formulate the fast release compression coated tablet of rabeprazole sodium. 4.To optimize the formulation using suitable experimental design.