The ancient Greek philosopher Plotinus insisted that philosophy should be concerned with nothing less than τo τιμιώτατον (to timiotaton), generally translated as "what matters most". This collection of philosophical conversations by many of the world's leading thinkers seeks to honour Plotinus' vision by addressing questions related to the art of living. When thinking about the art of living, we may conjure up ideas of therapy, meditation, peace, happiness, and so on. However, this collection aims to expand the scope of this idea, foregrounding social and political questions, alongside more traditional existential ones. How are we to think about the art of living together, of living with technology, of living under oppression, of living in the end times? These engaging and urgent conversations invite us to think anew about the complexities and challenges involved in living a good life in a world characterized by uncertainty and change.